Study on Interleukin-6 Produced from Human Gingival Fibroblasts.

Healthy Human Gingival Fibroblasts Cytokines on Interleukin-6 Production by Effect of Lipopolysaccharide and Inflammatory

CpG motifs in Porphyromonas gingivalis DNA stimulate interleukin-6 expression in human gingival fibroblasts.

We suggest here that Porphyromonas gingivalis DNA may function as a virulence factor in periodontal disease through expression of inflammatory cytokine. The bacterial DNA markedly stimulated in a dose-dependent manner interleukin-6 (IL-6) production by human gingival fibroblasts. The stimulatory action was eliminated by treatment with DNase but not RNase. The stimulatory effect was not observed...

Signaling mechanisms involved in protease-activated receptor-1-mediated interleukin-6 production by human gingival fibroblasts.

Human gingival fibroblasts (HGFs) express protease-activated receptor-1 (PAR-1) at high levels. In cultured HGFs, we studied the signaling pathway of thrombin-induced interleukin-6 (IL-6) production. The PAR-1 agonist peptide SFLLRN mimicked the thrombin-induced IL-6 production in the presence of amastatin, an aminopeptidase inhibitor. Thrombin or a combination of SFLLRN and amastatin also stri...

Cytotoxic Potential of Vasoconstrictor Experimental Gingival Retraction Agents - in Vitro Study on Primary Human Gingival Fibroblasts (gingival margin retraction agents / cytotoxicity / human gingival fibroblasts)

The aim of this in vitro study was to evaluate the cytotoxic effects of the vasoconstrictor experimental gingival retraction agents (VEGRAs) in a dynamic setting. The strong cytotoxic effects of the astringent-based conventional gingival retraction agents (ACGRAs) on human gingival fibroblasts (HGFs) in vitro was our motivation to evaluate the biocompatibility of the vasoconstrictor-based exper...

Kaempferol Effects on Human Gingival Fibroblasts

Objective: Kaempferol is a natural flavonol found in many dietary fruits, vegetables, and medicinal herbs. It reportedly has multiple beneficial properties as analyzed in vivo and in vitro. The objective of this study was to determine cytoprotective, anti-inflammatory, and wound healing characteristics of kaempferol in cultured human gingival fibroblasts. Materials & Methods: To determine cytot...